Panel layout matters. Originally all six of these panels were going to be the same size. However, this made it a bit confusing to figure out which order they were meant to be read in. Do you go left to right first or top to bottom? Most Western readers naturally read left to right first, but any ambiguity can throw someone out of the story. So by playing with the panel sizes just a tad, I was able to offset the rows of panels enough so the reading order is more clear. The first panel (upper left) extends past the bounds of the fourth panel (lower left), so the eye more easily flows to the right instead of down. Anything you can do to make your comic an easier, clearer, and more pleasant reading experience is critical!